Featured Publications
Meisel JD, Joshi PR, Spelbring AN, …, Barondeau DP, Ruvkun G*, Mootha VK*. Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency. Nature 2025
Meisel JD, Miranda M, Skinner OS, …, Jourdain AA, Ruvkun G*, Mootha VK*. Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell 2024
Meisel JD, Wiesenthal PP, Mootha VK*, Ruvkun G*. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Current Biology 2024
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Meisel JD, Joshi PR, Spelbring AN, Wang H, Wellner SM, Wiesenthal PP, Miranda M, McCoy JG, Barondeau DP, Ruvkun G*, Mootha VK*. Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency. Nature (2025)
Marutani E, Miranda M, Durham TJ, Kim SH, Russell DL, Wiesenthal PP, Lichtenegger P, Menard MA, Brzozowski CF, Li H, Ruvkun G, Meisel JD, Volpicelli-Daley L, Mootha VK, Ichinose F. Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease. Nature Neuroscience (2025)
Meisel JD, Wiesenthal PP, Mootha VK*, Ruvkun G*. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Current Biology (2024)
Featured in News & Views: RNA: De-silencing to the rescue
Lee H, Boor SA, Hilbert ZA, Meisel JD, Park J, Wang Y, McKeown R, Fischer SEJ, Andersen EC, Kim DH. Genetic variants that modify neuroendocrine gene expression and foraging behavior of C. elegans. Science Advances (2024)
Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G*, Mootha VK*. Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell (2024)
Boor SA, Meisel JD, Kim DH. Neuroendocrine gene expression coupling of interoceptive bacterial food cues to foraging behavior of C. elegans. Elife (2024)
Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ, Goodman RP, Grabarek Z, Haas ME, Hung WHW, Joshi PR, Jourdain AA, Kim SH, Kotrys AV, Lam SS, McCoy JG, Meisel JD, Miranda M, Panda A, Patgiri A, Rogers R, Sadre S, Shah H, Skinner OS, To TL, Walker MA, Wang H, Ward PS, Wengrod J, Yuan CC, Calvo SE, Mootha VK. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Research (2021)
Park J, Meisel JD, Kim DH. Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans. PLoS Genetics (2020)
Ast T*, Meisel JD*, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell (2019)
Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK. MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca(2+) and Mn(2+). Proc Natl Acad Sci U S A (2018)
Meisel JD, Kim DH. Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans. Current Biology (2016)
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Berube PM, Biller SJ, Kent AG, Berta-Thompson JW, Roggensack SE, Roache-Johnson KH, Ackerman M, Moore LR, Meisel JD, Sher D, Thompson LR, Campbell L, Martiny AC, Chisholm SW. Physiology and evolution of nitrate acquisition in Prochlorococcus. ISME J (2015)
Meisel JD, Panda O, Mahanti P, Schroeder FC, Kim DH. Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell (2014)
Meisel JD, Kim DH. Behavioral avoidance of pathogenic bacteria by Caenorhabditis elegans. Trends Immunol (2014)
Scimone ML, Meisel J, Reddien PW. The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea. Development (2010)